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June 28, 2026PLoS ONEOpen Access

Comparison of two algorithms of APTT-based lupus anticoagulant assay, two Dilute Russell viper venom time reagents, and silica clotting time

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Authors

PWPreechaya WongkrajangTPTitiwan PientongRHRatchaneekorn Hanyongyuth

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Overview

Retrospective analysis compares lupus anticoagulant detection methods, suggesting significant variations in positivity rates.

Key Points

  • The study aims to evaluate and compare different algorithms for detecting lupus anticoagulants in citrated plasma samples.
  • Retrospective analysis of 135 citrated plasma samples for lupus anticoagulant testing.
  • Assessment of five detection approaches: APTT-based assay, and four integrated assays including dRVVT and silica clotting time.
  • Evaluation of inter-assay agreement and associations with anticardiolipin and anti-β2-glycoprotein I antibodies.
  • LA positivity rates varied from 19.3% to 35.6% across methods at the 97.5th percentile.
  • The application of the 99th percentile decreased positivity rates for dRVVT-HemosIL and APTT-based assays.
  • APTT-based assays showed the strongest associations with anticardiolipin and anti-β2-glycoprotein I antibodies.

Cite This Study

Wongkrajang et al. (2026) studied this question.

synapsesocial.com/papers/6a40ba8861bb0a67205c654ahttps://doi.org/10.1371/journal.pone.0352430
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