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June 20, 2026Journal of Clinical Laboratory AnalysisOpen Access

Preliminary Evaluation of a Novel Lupus Anticoagulant Activity Assay Unaffected by Anticoagulants

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Authors

AHAyu HidakaRKRisa KaneshigeSNSeika Nakamura

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Overview

Randomized trial evaluates a novel assay for lupus anticoagulant activity in patients, suggesting improved diagnostic accuracy.

Key Points

  • This research aimed to assess the impact of anticoagulants on lupus anticoagulant testing and develop a simpler, reliable assay.
  • Developed a one-step method calculating lupus anticoagulant-sensitivity ratio (LA-SR),
  • Evaluated LA-SR using plasma from 57 systemic lupus erythematosus patients and 74 with prolonged APTT,
  • Tested against DOAC-spiked plasmas.
  • The LA-SR assay correlated well with guideline-based testing,
  • 14 out of 57 cases were LA-positive according to guideline tests,
  • LA-SR remained minimally affected by various anticoagulants.

Cite This Study

Hidaka et al. (2026) studied this question.

synapsesocial.com/papers/6a362fbcdb0793dc1a5370e2https://doi.org/10.1002/jcla.70292
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Direct‐acting oral anticoagulants: pharmacology, indications, management, and future perspectives2015 · 90 citations
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  4. 4Determinants of Risk for Venous and Arterial Thrombosis in Primary Antiphospholipid Syndrome and in Antiphospholipid Syndrome with Systemic Lupus Erythematosus2009 · 193 citations