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May 8, 2026Current Opinion in ImmunologyOpen Access

The role of different aPL subpopulations in the lupus anticoagulant phenomenon

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Authors

DADeepa J ArachchillageMEMaria EfthymiouHCHannah Cohen

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Overview

Review outlines mechanisms of antiphospholipid subpopulations affecting lupus anticoagulant activity, suggesting clinical relevance.

Key Points

  • This review investigates how different subpopulations of antiphospholipid antibodies contribute to lupus anticoagulant activity and their implications.
  • Summarised mechanisms of antiphospholipid antibody subpopulations generating lupus anticoagulant activity.
  • Discussed pathophysiological and clinical implications of lupus anticoagulant.
  • Reviewed laboratory detection methods and challenges in testing.
  • Lupus anticoagulant is strongly associated with thrombosis and pregnancy complications.
  • Detection relies on clotting assays, with technical challenges noted in anticoagulated patients.
  • Biological variability and assay heterogeneity influence lupus anticoagulant testing outcomes.

Cite This Study

Arachchillage et al. (2026) studied this question.

synapsesocial.com/papers/69fd7d4abfa21ec5bbf05cb3https://doi.org/10.1016/j.coi.2026.102784
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Testing for the lupus anticoagulant: the good, the bad, and the ugly2024 · 21 citations
  2. 2Antiphospholipid Syndrome and Lupus Anticoagulant: Where do we stand today ?2024
  3. 3Laboratory Diagnosis of Lupus Anticoagulants: A Systematic Review of Assay Performance, Pre-analytical Challenges, and Clinical Utility2025
  4. 4Comparison of two algorithms of APTT-based lupus anticoagulant assay, two Dilute Russell viper venom time reagents, and silica clotting time2026
  5. 5Preliminary Evaluation of a Novel Lupus Anticoagulant Activity Assay Unaffected by Anticoagulants2026