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This is a Cross-Sectional Study study.

October 3, 2025Clinical ChemistryOpen Access

A-269 A sepsis diagnostic platform using host protease activity sensors

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MALDI-TOF MS method improves diagnostic specificity and sensitivity in sepsis detection, indicating better outcomes.

The MALDI-TOF MS-based assay provides enhanced sensitivity and specificity for sepsis diagnosis, outperforming traditional biomarkers.
Combining HNE and MMP enzyme activity analysis significantly improves the differentiation between sepsis and non-sepsis patients.
The area under the ROC curve exceeds 90%, demonstrating the diagnostic potential of the proposed platform for sepsis detection.
This method offers a cost-effective diagnostic tool that may reduce unnecessary antibiotic use and hospital stay durations.

Dapeng Chen (2025) studied this question.

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