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This is a Quantitative Study study.

October 3, 2025Clinical ChemistryOpen Access

A-348 Pediatric reference intervals for 12 enzymes, proteins, and lipids on the Roche cobas® pro Integrated System established using the CALIPER cohort of healthy children

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New pediatric reference intervals for 12 biomarkers were established using the Roche cobas® pro system, enhancing pediatric test interpretation.
Age and sex partitioning identified variations in reference values, aligning with previous CALIPER findings across different analytical platforms.
The study utilized a comprehensive method involving 300–500 CALIPER samples from children aged 0-18 to ensure reliability in partitions.
The results highlight the importance of accurate reference intervals in clinical practice, especially for liver and renal function markers in pediatrics.

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This research establishes pediatric reference intervals for enzymes and proteins in children, indicating their clinical significance.

Jung et al. (2025) studied this question.

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