What question did this study set out to answer?

The study aims to establish age-specific reference intervals for serum biochemical analytes in healthy Chinese children.

Establishment of Reference Intervals for 41 Serum Biochemical Analytes in Healthy Chinese Children

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Randomized trial establishes age-specific reference intervals in healthy Chinese children, suggesting improved pediatric diagnostics.

The study aims to establish age-specific reference intervals for serum biochemical analytes in healthy Chinese children.
Collected 2627 residual serum samples from children aged 28 days to 17 years at Shenzhen Baoan Women's and Children's Hospital.
Measured 41 biochemical analytes using the Mindray BS-2800M analyzer and established reference intervals according to CLSI guidelines.
Evaluated pediatric patterns of estimated glomerular filtration rate using multiple equations.
Thirty-six analytes showed consistency with comparative studies, except for triglyceride and anti-streptolysin O.
Distinct age-dependent dynamics were found in 21 analytes, including liver enzymes and renal biomarkers.
eGFR increased rapidly during the first two years, with variability noted among different formulas.

Liu et al. (2026) studied this question.

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