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Pediatric reference intervals for 27 routine chemistry analytes in healthy children and adolescents on the Roche cobas pro platform

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Randomized trial establishes pediatric reference intervals for 27 chemistry analytes, highlighting variations by age and sex.

The aim is to establish robust age- and sex-specific reference intervals for 27 routine chemistry analytes in healthy children and adolescents.
Conducted a study under the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER).
Analyzed serum samples from 300 to 500 healthy children and adolescents (birth to <19 years) per analyte.
Established reference intervals using nonparametric methods following CLSI guidelines.
All assays met analytical performance criteria, with imprecision <4%.
Age-specific partitions were needed for 23 out of 27 analytes, and sex-specific partitions for select markers during adolescence.
Electrolytes like sodium and chloride showed stable reference intervals, while others varied based on growth and metabolism.

Jung et al. (2026) studied this question.

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