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October 3, 2025British Journal of HaematologyOpen Access

Prognostic significance of pretransplant 18F‐FDG PET/CT metrics in relapsed/refractory diffuse large B‐cell lymphoma with partial response to salvage chemotherapy prior to autologous stem cell transplantation

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Authors

MSM. SuhAsan Medical CenterJHJaewon HyungUlsan CollegeCPChan Sik ParkUlsan College

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Implication

Retrospective analysis identifies SUVTLR ≥4.2 as a predictor of inferior event-free survival in DLBCL patients, suggesting improved prognostication beyond visual assessment.

Key Points

  • Interim SUVTLR ≥4.2 predicts inferior event-free survival at 9.87 months in R/R DLBCL patients.
  • The hazard ratio for inferior EFS associated with interim SUVTLR was 1.25, indicating substantial risk.
  • Semiquantitative metrics from interim FDG PET/CT scans were more informative than visual Deauville scores in assessing prognosis.
  • The study involved a cohort of 50 patients with R/R DLBCL who achieved partial response to salvage chemotherapy.

Cite This Study

Suh et al. (2025) studied this question.

synapsesocial.com/papers/68e040eda99c246f578b3389https://doi.org/10.1111/bjh.70186
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of therapeutic effect and prognostic value of 18F-FDG PET/CT in different treatment nodes of DLBCL patients2024 · 9 citations
  2. 2Added prognostic value of baseline pre-infusion 18F-FDG PET/CT in diffuse large B-cell lymphoma patients receiving chimeric antigen receptor T-cell therapy2025
  3. 318F-FDG parameters as therapy response predictors in patients with diffuse large B-cell lymphoma: A single centre experience.2025 · 1 citations
  4. 4Early interim PET/CT predicts post-treatment response in diffuse large B-cell lymphoma2014 · 11 citations
  5. 5FDG‐PET/CT after two cycles of R‐CHOP in DLBCL predicts complete remission but has limited value in identifying patients with poor outcome – final result of a UK National Cancer Research Institute prospective study2020 · 42 citations