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October 3, 2025HaematologicaOpen Access

HES1 regulates bone marrow mesenchymal stromal cell function by suppressing NFATc2-mediated inflammation

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Authors

AZAnthony Z. ZhuZMZhilin MaEWEmily V. Wolff

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Overview

Observational analysis shows HES1 influences inflammation in mesenchymal stromal cells, suggesting potential therapeutic targets.

Key Points

  • HES1 is crucial for maintaining bone marrow mesenchymal stromal cell homeostasis, especially under stress.
  • Deletion of Hes1 in bone marrow reduces mesenchymal stromal cell frequency and impairs hematopoiesis support.
  • Pharmacological inhibition of inflammation can rescue Hes1-KO mesenchymal stromal cell functions.
  • Research reveals HES1's role in regulating NFATc2 to suppress inflammation in bone marrow stromal cells.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/68e040f3a99c246f578b3885https://doi.org/10.3324/haematol.2025.288138
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