Supplementary Figure S14 from Blocking M2-Like Macrophage Polarization Using Decoy Oligodeoxynucleotide-Based Gene Therapy Prevents Immune Evasion for Pancreatic Cancer Treatment

Supplementary Figure S14. The expression of Granzyme B is significantly increased in mouse pancreatic tumors treated with STAT6-CYBB ODN. A, IHC staining for the cytotoxic marker Granzyme B was performed in KPC tumors from the scrambled ODN, mutated ODN, and STAT6-CYBB ODN-treated mice. B, The bar graph depicts the average numbers of granzyme B positive cells per field. ***, p < 0.001, compared to the scrambled ODN treatment group. Five random fields of 3 random sections from each mouse were used to quantify the positive cells