October 1, 2024Clinical Chemistry

A-159 Re-evaluating Ferritin Cutoffs for the Diagnosis of Iron Deficiency and Iron Deficiency Anemia

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Authors

KTKatie TroikeCleveland Clinic AMA. J. McShaneCleveland Clinic

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Implication

Patient data analysis reveals inadequate sensitivity of standard ferritin thresholds in clinical cohorts, highlighting the need for revised reference intervals.

Key Points

Diagnostic accuracy for iron deficiency improves when raising ferritin cutoffs toward 30 ng/mL, identifying depleted storage pools missed by standard lower limits.
Receiver operator characteristic curve analysis evaluated 26,455 patient profiles using transferrin saturation and hemoglobin to classify storage thresholds.
Highlights the critical need to revise ferritin reference intervals for iron deficiency anemia, especially to prevent underdiagnosis in female patient cohorts.

Cite This Study

Troike et al. (2024) studied this question.

synapsesocial.com/papers/68e5622ee2b3180350eff36e https://doi.org/10.1093/clinchem/hvae106.157

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Implication

Patient data analysis reveals inadequate sensitivity of standard ferritin thresholds in clinical cohorts, highlighting the need for revised reference intervals.

A-159 Re-evaluating Ferritin Cutoffs for the Diagnosis of Iron Deficiency and Iron Deficiency Anemia

Discussion

Member takes

Implication

Key Points

Cite This Study

A-159 Re-evaluating Ferritin Cutoffs for the Diagnosis of Iron Deficiency and Iron Deficiency Anemia

Discussion

Member takes

Implication

Key Points

Cite This Study

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