Key result
Diagnosing iron deficiency using TSAT ≤19.8% or Fe ≤13 μmol/l identified patients with more severe heart failure and a higher incidence of anemia (43.3% vs. 23.3%) than AHA/ESC/RSC criteria.
Why the study?
To compare clinical, anamnestic, and laboratory and instrumental data of patients with CHF and iron deficiency diagnosed by standard AHA/ESC/RSC criteria versus criteria based on decreased TSAT or serum iron.
Does the use of TSAT ≤19.8% or Fe ≤13 μmol/l criteria compared to AHA/ESC/RSC criteria identify a different clinical profile of iron deficiency in patients with CHF?
Population
498 patients with CHF
Comparison
AHA/ESC/RSC criteria vs TSAT ≤19.8% or serum Fe ≤13 μmol/l vs both criteria
Design
Post-hoc observational analysis
Authors
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Ferritin-based ID criteria may overdiagnose in CHF while missing severe cases; leaves open optimal thresholds for prospective trials.
Observational (n=498)
Does the use of TSAT ≤19.8% or Fe ≤13 μmol/l criteria compared to AHA/ESC/RSC criteria identify a different clinical profile of iron deficiency in patients with CHF?
Absolute Event Rate: 43.3% vs 23.3%
Ferritin-based criteria for iron deficiency in CHF may lead to overdiagnosis, whereas criteria based on low TSAT or serum iron better identify patients with severe clinical and functional impairment.
Mareev et al. (2024) conducted an observational in Chronic heart failure (n=498). Iron deficiency diagnosed by TSAT ≤19.8% or Fe ≤13 μmol/l vs. Iron deficiency diagnosed by AHA/ESC/RSC criteria was evaluated on Incidence of anemia. Diagnosing iron deficiency using TSAT ≤19.8% or Fe ≤13 μmol/l identified patients with more severe heart failure and a higher incidence of anemia (43.3% vs. 23.3%) than AHA/ESC/RSC criteria.
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