Mendelian randomization suggests a causal link between glycemic traits and thoracic aortic structures and diseases

We investigates the relationship between glycemic traits, specifically Type 2 diabetes mellitus (T2DM), fasting glucose, fasting insulin, glycated hemoglobin, and 2 hour post load glucose and thoracic aortic morphology and diseases. The results indicate an inverse association between elevated glycemic traits and aortic diameters, as well as a reduced risk of thoracic aortic aneurysm. Specifically, genetic predictors beta-cell proinsulin mechanism in T2DM, drive these associations. Key genes such as AGER, GLRX, TCF7L2, and GCK are implicated in this process, highlighting their potential for leveraging these genetic targets to explore therapeutic avenues for the prevention and treatment of TAAD Given their role in glycemic control medication.