Maintainance of extracellular volume and water balance is important in cellular metabolism and these properties confer to sodium profile, but overconsumption of sodium causes risk to health. The present study aimed to develop and evaluate fast-dissolving effervescent tablets using a novel two-step wet granulation method, incorporating Olive (Olea europaea), halophyte marsh plant (Salicornia herbacea L.) and bamboo silica salts natural ingredients and edible organic acids viz. citric acid, malic acid, tartaric acid, apple cider vinegar powder, fumaric acid and alkalizing agents like sodium bicarbonate, anhydrous potassium carbonate, anhydrous sodium carbonate, potassium sulphate dodecahydrate as active ingredients to enhance bioavailability and dissolution. During the process, all active ingredients were milled separately and sifted through a number 40 mesh sieve, followed by blending for 10 min to create uniform wet mass and further, sieved through number 20 mesh to produce granules. Finally, the dried granules of the composition according to formulations were compressed into tablets with 12 mm diameter using a single punch tablet punching machine. The formulations adhered to pharmacopoeial quality standards, displaying favorable mechanical and physical properties. The results revealed that the effervescent granules in all the formulations exhibited excellent flow properties with Angle of Repose, Hausner’s ratio and compressibility index in the ranges of 26.10°-29.52°, 1.07-1.12 and 6.12%-10.51% respectively. Formulations F1 and F3 emerged as the most effective, with friability <0.5%, water content <0.05%, effervescence time <2.5 min and excellent solubility on the Likert scale. The findings open avenues for further research into effervescent technology and its application in drug delivery systems.
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Wasim et al. (2024) studied this question.
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