Blinded screen identification of MAPK/ERK pathway inhibitors. A, Violin plot showing the vulvae/adult score distribution of screened compounds after applying exclusion criteria. B, Hit validation of 1° hits. The plot shows the mean values for duplicate experiments. C, Violin plot showing percent adults with the Muv phenotype after treatment with validated 1° hits in lin-1(e1777) mutants. Compound names after unmasking are indicated in B and C.
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Gorgoń et al. (2024) studied this question.
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