Supplementary Figure S3 from Autocrine 17-β-estradiol/estrogen receptor-α loop determines the response to immune-checkpoint inhibitors in non-small cell lung cancer

Outcome of non-small cell lung cancer patients in LUAD TCGA cohort. a. OS of patients of lung adenocarcinoma (LUAD) dataset of The Cancer Genome Atlas (TCGA), stratified according to the gender. F: females; M: males. b-c. OS of LUAD TCGA female and male patients, stratified according to the median expression value of CD274/PD-L1 mRNA. d-e. OS of LUAD TCGA female and male patients, stratified according to the median expression value of ESR1/ERα mRNA. f-g. OS of LUAD TCGA female and male patients, stratified according to the co-expression phenotypes: CD274high/ESR1high, CD274high/ESR1low, CD274low/ESR1high, CD274low/ESR1low. P:0.005 for CD274high/ESR1high versus CD274low/ESR1low group. h. Expression of ERα mRNA, plotted versus PD-L1 mRNA, both measured by RT-PCR (technical triplicates) in the tumor samples from F and M patients.