Phytochemical study on the methanol extract of the leaves of Phyllanthus reticulatus led to the isolation of two new compounds, phyllanretiosides A ( 1 ) and B ( 2 ) together with ten known ones ( 3 – 12 ). Their chemical structures were determined by HR‐ESI‐MS, NMR, and ECD spectra in comparison with the literature. Three ellagitannins, phyllanretioside A ( 1 ), corilagin ( 3) , and phyllanthusiin C ( 4) inhibited lipopolysaccharide(LPS)‐induced nitric oxide production in RAW 264.7 cells with IC 50 values of 63.2, 83.2, and 5.6 μM, respectively. In addition, compounds 1 , 3 , and 4 exhibited significantly antimicrobial activity (MICs: 16–128 μg/mL) towards some of seven microbial strains.
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Yến et al. (2024) studied this question.