Figure 4 from Mast Cell Infiltration and Subtype Promote Malignant Transformation of Oral Precancer and Progression of Oral Cancer

A, MCs promote tumor growth in vivo. Allograft model of the dorsal of tongue of the C3H / HeJ mouse using the squamous cell carcinoma cell line SCC7. B, A larger tumor volume was found in the experimental group compared with the control group at 7, 9, 11, 13, and 15 days. C, Weight of mice inoculated with a mixture of SCC7 and BMMCs was lower than that of mice inoculated with a mixture of SCC7 and PBS at 14 to 16 days. D and E, Mice inoculated with a mixture of SCC7 tumor cells and BMMCs showed a significantly higher volume. F and G, H&E staining identified the development of OSCC, and more CD117 (marker of MCs, P = 0.048), Ki67 (P < 0.001), and pan-CK (P < 0.001) positive cells found in the group inoculated with a mixture of SCC7 and BMMCs, whereas more CD8 positive cells were found in the control group. *, P < 0.05; ***, P < 0.001.