Supplementary Figure 1 from Mast Cell Infiltration and Subtype Promote Malignant Transformation of Oral Precancer and Progression of Oral Cancer

Supplementary Figure 1. The spatial distance between mast cells, CD8+ cells and cancer cells (A). The distances between MCTC and CD8+ cells (B), as well as between MCT and CD8+ cells (C), were lower in OSCC than in OLK within a radius of 40µm, 60µm, 80µm, and 100µm, but there is no significant difference between them within a radius of 20µm. The greater distances were found between MCTC and cancer cells compared to MCT and cancer cells in OSCC within a radius of 20µm, 40µm, 60µm, 80µm, and 100µm (D). The distances between MCT and CD8+ cells within a radius of 20µm were grouped based on the standardized log-rank statistic (E), and the KM curve survival analyses showed that the greater distance between MCT and CD8+ cells within a radius of 20µm was associated with poor survival of OSCC (F). *, P < 0.05; **, P < 0.01; ***, P < 0.001; ns, not significant.