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October 8, 2025MedicineOpen Access

Gut microbiota influences lung cancer risk through circulating cytokines—Insights from a Mendelian randomization study

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Authors

WSWei ShenRHRuikun HouJZJianjie Zhang

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Overview

This research demonstrates the causal link between gut microbiota and lung cancer risk through cytokines, indicating potential preventive strategies.

Key Points

  • Gut microbiota influences lung cancer risk through circulating cytokines, highlighting a potential preventive avenue.
  • Mendelian randomization identified six cytokines significantly regulating the risk of squamous cell carcinoma, adenocarcinoma, and small cell lung cancer.
  • Mediation analysis sheds light on the role of cytokines as mediators between gut microbiota and lung cancer risk, providing new insights into cancer prevention.
  • Squamous cell carcinoma appears more impacted by cytokines compared to adenocarcinoma and small cell lung cancer, suggesting cancer-specific pathways.

Cite This Study

Shen et al. (2025) studied this question.

synapsesocial.com/papers/68e5c1be6950a706b22b57ddhttps://doi.org/10.1097/md.0000000000044897
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