pTSA-catalyzed synthesis of functionalized chromeno[2,3-d]pyrimidine/chromeno[4,3-b]chromene derivatives via one-pot three component reaction: mechanistic insights and variable temperature NMR studies to investigate restricted bond rotation

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This is a Experimental Study study.

Yogesh Bhaskar Singh Tanwer; Suman Sourabh; Sabyasachi Bhunia; Sanchari Pal; Debjit Das

doi:10.1039/d5ra06198a

January 1, 2025RSC AdvancesOpen Access

pTSA-catalyzed synthesis of functionalized chromeno[2,3-d]pyrimidine/chromeno[4,3-b]chromene derivatives via one-pot three component reaction: mechanistic insights and variable temperature NMR studies to investigate restricted bond rotation

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Key Points

The method efficiently synthesizes functionalized chromeno derivatives, showcasing its versatility and effectiveness.
Using P TSA, the reaction features a one-pot approach, fostering an efficient synthesis involving multiple components.
NMR studies provided detailed mechanistic insights, illustrating the significance of restricted bond rotation in the synthesis.
The findings indicate potential applications for the synthesized derivatives in various fields such as pharmaceuticals.

Implication

An efficient method synthesizes chromeno derivatives using P TSA, highlighting mechanistic insights and NMR studies.

Abstract

An efficient method is presented for the synthesis of chromeno[2,3- d ]pyrimidine/chromeno[4,3- b ]chromene derivatives via p TSA-catalyzed cyclization of 1,3-dimethylbarbituric acid/4-hydroxycoumarin, electron-rich arenes, and various salicylaldehydes.

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Cite This Study

Tanwer et al. (2025) studied this question.

synapsesocial.com/papers/68e5c1c36950a706b22b5bfc https://doi.org/10.1039/d5ra06198a

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pTSA-catalyzed synthesis of functionalized chromeno[2,3-d]pyrimidine/chromeno[4,3-b]chromene derivatives via one-pot three component reaction: mechanistic insights and variable temperature NMR studies to investigate restricted bond rotation

Key Points

Implication

Abstract

Discussion

Cite This Study

pTSA-catalyzed synthesis of functionalized chromeno[2,3-d]pyrimidine/chromeno[4,3-b]chromene derivatives via one-pot three component reaction: mechanistic insights and variable temperature NMR studies to investigate restricted bond rotation

Key Points

Implication

Abstract

Discussion

Cite This Study

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