Distinct Reactivity of Aromatic and Aliphatic Thiols for the Efficient Synthesis of Chromeno[2,3-d]pyrimidine and Chromeno[4,3-b]chromene Derivatives: Mechanistic Investigations and Reaction Scope

Q: What does this research mean for the field?

A pTSA-catalyzed multicomponent cyclization protocol enables the efficient synthesis of chromeno[2,3-d]pyrimidine and chromeno[4,3-b]chromene derivatives, demonstrating distinct reactivities between aromatic and aliphatic thiols. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Suman Sourabh; Yogesh Bhaskar Singh Tanwer; Raj Rani; Sabyasachi Bhunia; Sanchari Pal; Debjit Das

doi:10.1039/d6ob00585c

January 1, 2026Organic & Biomolecular Chemistry

Distinct Reactivity of Aromatic and Aliphatic Thiols for the Efficient Synthesis of Chromeno[2,3-d]pyrimidine and Chromeno[4,3-b]chromene Derivatives: Mechanistic Investigations and Reaction Scope

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Key Points

To investigate the reactivity of aromatic and aliphatic thiols in synthesizing chromeno derivatives through a new cyclization method.
Developed a three/two-component cyclization protocol using pTSA as a catalyst.
Investigated the reaction of substituted salicylaldehyde and 1,3-dimethylbarbituric acid with thiols.
Explored various reaction conditions to assess their impact on synthesis efficiency.
Successfully synthesized chromeno[2,3-d]pyrimidine derivatives with high yields.
Demonstrated the distinct reactivity patterns between aromatic and aliphatic thiols.
Provided mechanistic insights into the cyclization process, expanding the reaction scope.

Implication

Reveals distinct reactivity of thiols in synthesizing valuable chromeno derivatives, suggesting versatile applications.

Abstract

In this study, an efficient and convenient three/two-component cyclization protocol is presented for the development of synthetically valuable chromeno[2,3‐d]pyrimidine derivatives via pTSA-catalyzed reaction of substituted salicylaldehyde, 1,3-dimethylbarbituric acid, and both...

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Cite This Study

Sourabh et al. (2026) studied this question.

synapsesocial.com/papers/6a28fff36f82f25be989cba4 https://doi.org/10.1039/d6ob00585c

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Distinct Reactivity of Aromatic and Aliphatic Thiols for the Efficient Synthesis of Chromeno[2,3-d]pyrimidine and Chromeno[4,3-b]chromene Derivatives: Mechanistic Investigations and Reaction Scope

Key Points

Implication

Abstract

Discussion

Cite This Study

Distinct Reactivity of Aromatic and Aliphatic Thiols for the Efficient Synthesis of Chromeno[2,3-d]pyrimidine and Chromeno[4,3-b]chromene Derivatives: Mechanistic Investigations and Reaction Scope

Key Points

Implication

Abstract

Discussion

Cite This Study

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