Common T1 mapping methods are dependent on the biophysical model assumptions. Previous work based on a qMT-SPGR framework demonstrated the influence of magnetization transfer effects and the importance of appropriate sequence design and signal modelling for T1 estimation. In this work, we expanded upon this optimized framework using an MP2RAGE sequence and demonstrated that quantitative T1 values in agreement with VFA-based experiments can be obtained in the human brain.
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Soustelle et al. (2024) studied this question.
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