Sex-specific grey matter atrophy and brain-behavior relationships in CADASIL

This is the authors' abstract. We don't add key points for this paper.

The potential neurobiological substrates for sex differences in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) are largely unexplored. In this study, we explored the sex-specific neuroanatomical mechanisms of CADASIL. Greater grey matter atrophy was found in the frontotemporal cortex in male CADASIL. Working memory was associated with volumes in the bilateral orbitofrontal cortex and left entorhinal cortex among female CADASIL. The current findings indicate that sex affects the pathogenesis of CADASIL, ranging from differences in neuroanatomy to those in behavioral performance.