Partial Volume Averaging of Diffusion Tensor Imaging in the Fornix

Diffusion Tensor Imaging of the fornix promises to serve as an imaging biomarker for cognitive decline in multiple sclerosis and Alzheimer’s disease. As the fornix is surrounded by cerebrospinal fluid in the lateral ventricles, partial volume averaging can bias measures of tissue microstructure. Here, we use a high spatial resolution, multishell acquisition to test the methods for combating partial volume averaging in the fornix.