Head-to-head Comparison of Free Water Elimination Methods in Fornix

Diffusion Tensor Imaging measures in fornix may serve as a biomarker in Alzheimer’s disease. However, partial volume averaging between the fornix and surrounding cerebrospinal fluid imposes systematic bias that can conflate tissue microstructure with atrophy. Free Water Elimination methods have been proposed as a solution, but comparison between these methods is limited. We perform direct comparison between the approaches in terms of repeatability and bias.