Imaging measures of tissue microstructure of the fornix are are potential biomarkers for cognitive decline in Alzheimer’s disease (AD). However, partial volume averaging (PVA) between the fornix and cerobrospinal fluid can be substantial. As a result, measured changes may reflect atrophy, not changes in tissue microstructure. Neurite Orientation Dispersion and Direction Imaging and Free Water Elimination diffusion tensor imaging account for PVA. We present results from a cohort of AD patients, patients with mild cognitive impairment (MCI) and cognitively normal (CN) subjects, showing that NODDI and DTI measures correlate with specific scores cognitive status.
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Sakaie et al. (2024) studied this question.
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