Epidemiology studies have detected type 2 diabetes (T2D) increasing the risk of Alzheimer’s disease (AD). How insulin insensitivity in T2D influences AD onset/progression poses a puzzling question. In this study using dynamic nuclear polarization (DNP) magnetic resonance (MR) experiments, we interrogated the metabolic alteration by following the conversion of [1-13C]Pyr in the brain of control (CRL), T2D with no AD (T2D-AD -/-), and T2D with AD (T2D-AD +/-) rats. Pyruvate dehydrogenase (PDH) activity decreases in T2D and decreases further in T2D with AD.
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Datta et al. (2024) studied this question.
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