3D-MRSI using co-polarized HP [1-13C]pyruvate and [1-13C]dehydroascorbate to study a mouse model of Alzheimer's disease

Alzheimer’s disease (AD) is devastating and progressive disease. The non-invasive detection of early onset AD along with the mechanisms that drive its progression are still limited. Recent work has implicated metabolic reprogramming as an earlier AD potential indicator. Therefore, we investigated an AD mouse model at the early stage of development with the goal to evaluate whether co-hyperpolarized [1-13C]pyruvate and [1-13C]dehydroascorbate (DHA) along with 3D MRSI might provide insights into the brain metabolism of FAD mice at the onset of the disease. The metabolism of these translatable biomarkers would then give insight on our understanding of AD diagnosis and treatment.