Functional Connectivity in Smokeless Tobacco Dependent Users in a Craving ‘Primed’ State

Tobacco is a leading cause of preventable cancer and death and is consumed in various forms. There is a paucity of literature regarding cue-induced craving in smokeless tobacco, commonly found in the South East Asian Region. This study aimed to investigate the functional connectivity in a ‘primed’ state after cue-induced craving. We found facilitatory connectivity within salience network (SN) and inhibitory connectivity between default mode network (DMN) and anterior cingulate cortex (ACC) in smokeless tobacco users.