We synthesized an ultrasensitive 129Xe NMR probe with dual signals. It is a hollow nanoparticle composed of water-soluble CB[6]. It has two different hydrophobic cavities. Two 129Xe NMR signals with different chemical shifts can appear in a single detection, effectively avoiding the occurrence of false positive and false negative in complex biological environment detection, improving the accuracy and sensitivity of single detection, and has broad application prospects.
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Yuan et al. (2024) studied this question.
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