In-Vivo Simultaneous Hyperpolarized 129Xe MRI and [15O]-water PET Multi-Modal Imaging: A Proof of Concept Study

In this proof-of-concept study, simultaneous 129Xe-based MRI and [15O]-water PET images were collected and compared from rat brain. For initial validation phase in phantoms, we have dissolved 129Xe in [15O]-water to simultaneously use both imaging modalities and confirm that PET/MRI images reflect the true density of the 15O/129Xe. The comparison results show similarity between both imaging modalities and tracers, moving towards the next step in validating the Xenon imaging technique as a potential for brain perfusion measurement. The acquisitions were carried out using a 3T PET/MRI (Siemens Biograph mMR).