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August 13, 2024Antimicrobial Agents and ChemotherapyOpen Access

Bacteriophage therapy reduces Staphylococcus aureus in a porcine and human ex vivo burn wound infection model

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Authors

MMMichèle M. MolendijkErasmus MCBBBouke K. H. L. BoekemaTissue Regeneration Systems (United States)KLKirby R. LattweinErasmus MC

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Implication

Preclinical ex vivo study demonstrates reduction of Staphylococcus aureus in porcine and human burn models, highlighting the therapeutic potential of prophylactic phage application.

Key Points

  • Bacteriophage therapy reduced Staphylococcus aureus bacterial load across skin models, and prophylactic treatment notably enhanced overall therapeutic efficacy.
  • Assessment using porcine and human ex vivo skin models compared single application, successive treatments, and prophylaxis against fusidic acid control.
  • Highlights bacteriophage therapy as an effective alternative to antibiotics for burn wounds; preclinical ex vivo model, further clinical evaluation is needed.

Cite This Study

Molendijk et al. (2024) studied this question.

synapsesocial.com/papers/68e5c751b6db64358755dbcfhttps://doi.org/10.1128/aac.00650-24
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Also Consider

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  5. 5Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model2023 · 75 citations