These studies used Chinese hamster ovary cells that were cloned to express an angiotensin receptor ( At1ra) and a calcium indicator (R-GECO) to detect the release of angiotensin from brain slices containing the lamina terminalis of rats. Some of the experiments use tissue from renin knockout rats. The results support the existence of an angiotensin system in the brain that may involve alternative synthetic pathways and is upregulated by intermittent hypoxia.
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Farmer et al. (2024) studied this question.
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