Key result
Angiotensin-II infusion significantly increased mean arterial pressure (134 vs 98 mmHg) and induced up-regulation of AT1 receptor mRNA in the RVLM and down-regulation in the SFO.
Absolute Event Rate: 134% vs 98%
p-value: p=<0.05
Angiotensin-II-induced hypertension in rats is associated with up-regulation of AT1 receptors in the rostral ventrolateral medulla and down-regulation in the subfornical organ.
Hypothesis-generating for central AT1 plasticity in experimental hypertension; leaves open human translation and clinical relevance.
Blood-borne angiotensin-II (Ang-II) has profound effects in the brain. We tested the hypothesis that Ang-II-dependent hypertension involves differential Ang-II type I (AT(1)) receptors expression in the subfornical organ (SFO) and the rostral ventrolateral medulla (RVLM). Male Wistar rats were implanted with 14-day osmotic minipump filled with Ang-II (150 ng/kg/min) or saline. AT(1) receptor mRNA levels were detected in the SFO and RVLM by reverse transcription-polymerase chain reaction (RT-PCR). Ang-II caused hypertension (134 ± 10 mmHg vs. 98 ± 9 mmHg, n = 9, p < 0.05). RT-PCR revealed that Ang-II infusion induced increased AT(1) receptor mRNA levels in RVLM and decreased in SFO. Our data suggest that Ang-II-induced hypertension involves differential expression of brain AT(1) receptors.
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Valdir A. Braga (2011) studied Hypertension (n=53). Angiotensin-II vs. Saline was evaluated on Mean arterial pressure (mmHg) (p=<0.05). Angiotensin-II infusion significantly increased mean arterial pressure (134 vs 98 mmHg) and induced up-regulation of AT1 receptor mRNA in the RVLM and down-regulation in the SFO.
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