August 6, 2024Virology JournalOpen Access

Characterizing the splice map of Turkey Hemorrhagic Enteritis Virus

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AQAbraham QuayeBrigham Young University BPBrett E PickettBrigham Young University JGJoel S. Griffitts

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RNA sequencing reveals 34 distinct transcripts across Turkey Hemorrhagic Enteritis Virus, highlighting temporal regulation and novel open reading frames.

Key Points

Turkey Hemorrhagic Enteritis Virus generates 34 spliced transcripts organized into five transcription units, expanding the known coding capacity of the viral genome.
Analysis identified 29 novel spliced transcripts and six truncated open reading frames, altering previously annotated proteins during active viral replication.
Sanger sequencing validated novel viral splice junctions in turkey cell cultures, highlighting potential targets mediating viral immunosuppression.

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Quaye et al. (2024) studied this question.

synapsesocial.com/papers/68e5d46db6db64358756a447 https://doi.org/10.1186/s12985-024-02449-0

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Implication

RNA sequencing reveals 34 distinct transcripts across Turkey Hemorrhagic Enteritis Virus, highlighting temporal regulation and novel open reading frames.

Characterizing the splice map of Turkey Hemorrhagic Enteritis Virus

Discussion

Member takes

Implication

Key Points

Cite This Study

Characterizing the splice map of Turkey Hemorrhagic Enteritis Virus

Discussion

Member takes

Implication

Key Points

Cite This Study

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