August 5, 2024Advanced ScienceOpen Access

Lactylome Analysis Unveils Lactylation‐Dependent Mechanisms of Stemness Remodeling in the Liver Cancer Stem Cells

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FFFan FengChinese Academy of Sciences JWJiaqin WuChongqing University QCQingjia ChiAnhui University

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Implication

Lactylome and proteome analysis reveals that ALDOA lactylation promotes stemness in liver cancer stem cells, highlighting a promising therapeutic target for hepatocellular carcinoma.

Key Points

Enhanced aldolase A lactylation promotes liver cancer stem cell stemness by disrupting its binding to DDX17, which amplifies DDX17 regulatory activity in hepatocellular carcinoma.
Lactylome and proteome profiling of liver cancer stem cells identifies elevated glycolytic metabolism and ALDOA K230/322 lactylation alongside increased H3K56la modification.
Targeting lactylation pathways in liver cancer stem cells may offer a therapeutic strategy for hepatocellular carcinoma—preclinical cell models require further clinical validation.

Cite This Study

Feng et al. (2024) studied this question.

synapsesocial.com/papers/68e5d57fb6db64358756ba59 https://doi.org/10.1002/advs.202405975

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Implication

Lactylome and proteome analysis reveals that ALDOA lactylation promotes stemness in liver cancer stem cells, highlighting a promising therapeutic target for hepatocellular carcinoma.

Lactylome Analysis Unveils Lactylation‐Dependent Mechanisms of Stemness Remodeling in the Liver Cancer Stem Cells

Discussion

Member takes

Implication

Key Points

Cite This Study

Lactylome Analysis Unveils Lactylation‐Dependent Mechanisms of Stemness Remodeling in the Liver Cancer Stem Cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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