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June 20, 2026BioFactors

Lysine Lactylation: Dynamic Regulation in the Tumor Microenvironment and Clinical Translational Prospects

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Authors

YWYangmin WuBinzhou Medical UniversityXCX-D ChenSun Yat-sen UniversityZCZichang ChenGuangdong Medical College

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Implication

Review explores lysine lactylation's impact on tumor metabolism and immunity, suggesting clinical potential.

Key Points

  • This review explores the regulatory roles of lysine lactylation in the tumor microenvironment and its implications for clinical applications.
  • Systematic review of studies on lysine lactylation and its effects on tumor metabolism and immune response.
  • Analysis of key signaling pathways such as HIF-1α, mTOR, and NF-κB in regulating lysine lactylation.
  • Discussion of challenges in targeting lysine lactylation for clinical translation.
  • Lysine lactylation modifies histones and non-histone proteins, impacting tumor metabolism and immunity.
  • Targeting lactate metabolism enhances immune responses against tumors, increasing efficacy of immune checkpoint therapies.
  • Challenges include tumor heterogeneity and metabolic plasticity, necessitating further research.

Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/6a36300ddb0793dc1a537641https://doi.org/10.1002/biof.70126
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