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June 7, 2026Cell investigation.Open Access

Lactylation in concert with other post-translational modifications: Regulatory networks and disease implications

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Authors

ZFZiqi FuRSRuohan ShiLJLi Jiang

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Overview

This review synthesizes the role of lactylation in regulatory networks, linking cellular metabolism to disease implications.

Key Points

  • This review aims to elucidate the multifaceted roles of lactylation in post-translational modification networks and their implications for various diseases.
  • Synthesized mechanisms of lactylation-centered post-translational modification crosstalk.
  • Mapped interactions between lactylation and other modifications like acetylation and ubiquitination.
  • Proposed models for understanding lactylation's context-dependent regulatory functions.
  • Lactylation modulates inflammatory responses and tissue repair through chromatin-level orchestration.
  • Demonstrated crosstalk with ubiquitination impacts proteostasis, influencing disease processes such as drug resistance and sepsis.
  • Identified barriers to research including detection and specificity challenges in lactylation studies.

Cite This Study

Fu et al. (2026) studied this question.

synapsesocial.com/papers/6a250b2d7def13d035e1b3achttps://doi.org/10.1016/j.clnves.2026.100078
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protein lactylation in health and diseases: molecular mechanisms, biological significance, and clinical implications2026 · 3 citations
  2. 2Lysine lactylation in diseases: beyond histone lactylation2025
  3. 3Lysine lactylation in diseases: beyond histone lactylation2025
  4. 4Lysine Lactylation: Dynamic Regulation in the Tumor Microenvironment and Clinical Translational Prospects2026 · 1 citations
  5. 5Crosstalk between lactylation and other post-translational modifications in health and diseases2026 · 1 citations