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November 28, 2025Cell Death and DiseaseOpen Access

Lysine lactylation in diseases: beyond histone lactylation

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Authors

YLYiming LiuXGXuan GuoXHXinyang Hu

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Overview

This review illustrates how post-translational modifications impact pathogenesis in infectious diseases and inflammatory disorders, suggesting therapeutic targets.

Key Points

  • Elevated lactate in cells influences lysine lactylation, affecting disease outcomes, and signaling pathways.
  • Post-translational modification of proteins impacts transcriptional regulation and biological function in key disease contexts.
  • Analysis of phosphoproteins demonstrates their role in disease mechanisms like inflammation and infection.
  • Understanding these epigenetic mechanisms may enable better therapeutic strategies in managing various diseases.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/6928f12ea65b730b9ea7a755https://doi.org/10.1038/s41419-025-08223-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lysine lactylation in diseases: beyond histone lactylation2025
  2. 2Protein lactylation in health and diseases: molecular mechanisms, biological significance, and clinical implications2026 · 3 citations
  3. 3Lactylation in concert with other post-translational modifications: Regulatory networks and disease implications2026
  4. 4Lysine <scp>l</scp> ‐Lactylation: Bridging Metabolism, Chromatin and Disease2026
  5. 5The role of lactylation in age-related diseases: a molecular perspective2026 · 1 citations