Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 14, 2026Cell ProliferationOpen Access

Lysine l ‐Lactylation: Bridging Metabolism, Chromatin and Disease

View Full Paper
Ask AI
Bookmark
Share

Authors

AMAnoosha MalikMDMuhammad DilawarJLJunguang Liao

Discussion

Loading...

Member takes

Overview

Review examines lysine L-lactylation's role in disease and potential therapies, highlighting its impact on metabolism and chromatin.

Key Points

  • This review aims to explore lysine L-lactylation's role in metabolic states, chromatin regulation, and associated diseases. It also discusses therapeutic strategies targeting this modification.
  • Reviewed literature on lysine L-lactylation across histone and non-histone substrates.
  • Analyzed mechanisms of lysine L-lactylation in various diseases including cancer and neurodegenerative disorders.
  • Identified enzymes regulating lysine L-lactylation and its crosstalk with other post-translational modifications.
  • Lysine L-lactylation is implicated in transcription regulation and multiple pathophysiological conditions.
  • Identified therapeutic approaches focusing on lysine L-lactylation may enhance clinical outcomes in various diseases.
  • Highlighted the potential of lysine L-lactylation to bridge cellular metabolism and chromatin regulation.

Cite This Study

Malik et al. (2026) studied this question.

synapsesocial.com/papers/6a55d16e5aafca87247f876chttps://doi.org/10.1111/cpr.70262
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lysine lactylation in diseases: beyond histone lactylation2025
  2. 2Lysine lactylation in diseases: beyond histone lactylation2025
  3. 3Protein lactylation in health and diseases: molecular mechanisms, biological significance, and clinical implications2026 · 3 citations
  4. 4Lactylation in concert with other post-translational modifications: Regulatory networks and disease implications2026
  5. 5Crosstalk between lactylation and other post-translational modifications in health and diseases2026 · 1 citations