Pyroglutamic acidosis in the setting of Staphylococcus aureus bacteremia treated with flucloxacillin—An uncommon cause of high anion gap metabolic acidosis

Key Clinical Message Pyroglutamic acidosis (PGA) or 5‐Oxoprolinuria is an uncommon and often overlooked cause of high anion gap metabolic acidosis (HAGMA). This case highlights the importance of systematically approaching HAGMA, and to consider PGA as a differential diagnosis when medications that disrupt the γ‐glutamyl cycle such as flucloxacillin and paracetamol are present.