Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 19, 2024Annals of Case ReportsOpen Access

An Unusual Case of Metabolic Acidosis: The GAP and Urine are the Clues

View Full Paper
Ask AI
Bookmark
Share

Authors

LLLina León-MachadoHospital Universitario La PazBBBegoña Rivas BecerraHospital Universitario La PazCVCristina VegaHospital La Paz Institute for Health Research

Discussion

Loading...

Member takes

Implication

Case report reveals severe high anion gap metabolic acidosis in a critical care patient, highlighting pyroglutamic acid as an underdiagnosed cause.

Key Points

  • Accumulation of pyroglutamic acid can induce severe high anion gap metabolic acidosis, presenting with marked hypokalemia and elevated urine pH.
  • A 19-year-old patient required over 1000 mEq/day of sodium bicarbonate to manage severe acidosis and hypokalemia following acetaminophen exposure.
  • Case presentation highlights that measuring the urinary anion gap and serum gaps is essential to detect pyroglutamic acid accumulation in the ICU.

Cite This Study

León-Machado et al. (2024) studied this question.

synapsesocial.com/papers/68e78a66b6db6435876fcfdahttps://doi.org/10.29011/2574-7754.101658
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Pyroglutamic acidemia: A cause of high anion gap metabolic acidosis2000 · 92 citations