Investigation of The Effects of Fatty Acids on Growth Hormone, Insulin-like Growth Factor 1, and Insulin- and Hormone-sensitive Lipase Levels in Rats

Objective: Several studies have investigated hormones such as growth hormone (GH), insulin (INS), insulin-like growth factor-1 (IGF-1), and hormonesensitive lipase (HSL).However, there is insufficient data on the effects of the combination of short-, medium-, and long-chain fatty acids on hormone concentrations in serum/tissue, including GH, INS, IGF-1, and HSL.The purpose of this study was to investigate the effects of butyric acid (BA), caprylic acid (CA), and oleic acid (OA) alone or in combination on GH, INS, IGF-1, and HSL secretion.Methods: Fifty-six male Wistar rats were used in the study.The animals were separated into 8 subgroups: control, BA, CA, OA, BA + CA, BA + OA, CA + OA, and BA + CA + OA groups.Fatty acids were administered orally to rats for 21 days.At the end of the study, GH, IGF, INS, and HSL levels were measured in serum using the enzyme-linked immunosorbent assay method.Results: BA administration reduced GH, IGF-1, and INS levels but had no significant effect on HSL levels.CA administration increased HSL levels but had no significant effect on GH, INS, and IGF-1 levels.OA administration increased GH and HSL levels but had no significant effect on IGF-1 and INS levels. Conclusion:The combined use of fatty acids increased GH levels while decreasing INS, IGF-1, and HSL levels.