Population
Intact rams chronically implanted with perihypophysial cannula and rams actively immunized against…
Comparison
Free fatty acid (Intralipid and heparin) infusion vs Saline infusion
Design
Preclinical
Authors
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No immediate implications for human GH therapy; hypothesis-generating for FFA-somatostatin interactions in sheep, requiring clinical translation studies.
Free fatty acids exert an inhibitory action on the growth hormone axis at both pituitary and hypothalamic levels in sheep, mediated partly through increased somatostatin secretion.
Briard et al. (1998) studied this question.
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