January 1, 1997Endocrine JournalOpen Access

Inhibition of GH Releasing Factor (GRF)-lnduced GH Secretion by Intraruminal Infusion of Volatile Fatty Acids (VFA) in Sheep.

View Full Paper

Ask AI

Bookmark

Population

5 castrated male sheep, fasted for 18 hours

Design

Preclinical

Follow-up

6 hours

Authors

NMNobuyoshi MATSUNAGAObihiro University of Agriculture and Veterinary Medicine TGTaisei GOKATohoku University KNK. T. NamHankyong National University

Discussion

Member takes

Implication

Caution against extrapolating ovine GH suppression to patients; leaves open VFA effects on pituitary function in other species.

Structured PICO

Population

5 castrated male sheep, fasted for 18 hours

Intervention

Intraruminal infusion of a VFA mixture solution (acetate, propionate, butyrate) at various rates (53.5, 107, and 214 mumol kg-1 min-1) over 6 h, with intravenous GRF injection (0.25 micrograms kg-1) at 4 h

Outcome

Basal plasma GH concentrations and area under the profiles for GH release in response to GRF injectionsurrogate

An increase in ruminal VFA concentration within the physiological range suppresses GH secretion from the ovine anterior pituitary.

Cite This Study

MATSUNAGA et al. (1997) studied this question.

synapsesocial.com/papers/6a88f4efcd9902a7ca126825 https://doi.org/10.1507/endocrj.44.133

View Full Paper

Ask AI

Bookmark

Inhibition of GH Releasing Factor (GRF)-lnduced GH Secretion by Intraruminal Infusion of Volatile Fatty Acids (VFA) in Sheep.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of GH Releasing Factor (GRF)-lnduced GH Secretion by Intraruminal Infusion of Volatile Fatty Acids (VFA) in Sheep.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider