Figure 2 from PTP4A2 Promotes Glioblastoma Progression and Macrophage Polarization under Microenvironmental Pressure

High levels of PTP4A2 in gliomas are associated with tumor aggressiveness and poor overall survival of patients. A,PTP4A1, 2, and 3 mRNA levels of normal samples (nontumor from the GTEx database), IDH-mutant (IDHmut) gliomas, and IDH wild-type GBM (from TCGA). B,PTP4A2 mRNA levels in GBM subtypes: proneural, classical, and mesenchymal, the most aggressive. C, Kaplan–Meier curve of overall survival of patients with GBM stratified according to the expression level of PTP4A1, 2, and 3 (from TCGA). Log-rank P value = 0.001. PTP4A1 high, n = 179; PTP4A1 low, n = 76; PTP4A2 high, n = 173; PTP4A2 low, n = 82; PTP4A3 high, n = 124; PTP4A3 low, n = 132. D, Enrichment in biological pathways involving PTP4A2-correlated genes in TCGA GBM data. Only the first five clusters of GO terms are displayed.