In vitro phenotype of P3 spheroids. A, Spheroid invasion assay in collagen I of Ctrl and PTP4A2-KO 1 and 2 P3 cells. The invasive area was measured after 24 hours. B, Spheroid invasion assay in collagen I of Ctrl and PTP4A2-OE. C, Proliferation assay of Ctrl and PTP4A2-KO P3 cells based on spheroid growth. Kruskal–Wallis test followed by Dunn tests.
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Chouleur et al. (2024) studied this question.