Figure 4 from PTP4A2 Promotes Glioblastoma Progression and Macrophage Polarization under Microenvironmental Pressure

Transcriptional modulation of proinflammatory markers in P3 xenografts. A, Gene expression of different markers expressed by the human tumor cells inside the mouse brain, normalized by luciferase expression. qPCR primers were specific to human genes. B, Gene expression of different markers expressed by the TME, arranged by typical cell types and phenotypes: total macrophages, proinflammatory, and protumoral. Expression was normalized by actin expression. qPCR primers were specific to mouse genes. Kruskal–Wallis test followed by Dunn tests for all the figures. n = 7–8 mice per group