Figure 5 from PTP4A2 Promotes Glioblastoma Progression and Macrophage Polarization under Microenvironmental Pressure

Phenotype of macrophages and microglia in P3 xenografts. A, Representative images of macrophages (CD45⁺ IBA1⁺ P2RY12⁻) and microglia (CD45⁺ IBA1⁺ P2RY12⁺) in the tumor core and in the contralateral brain of a control tumor. Red triangles indicate macrophages positive for both CD45 and IBA1 and negative for P2RY12. White triangles indicate microglia positive for CD45, IBA1, and P2RY12. B, Proportion of macrophages and microglia within the leukocyte population of the tumor core and contralateral brain of KO, Ctrl, and OE xenografts. C, Immunostaining of COX2 and IBA1 with representative images (left) and quantification (right). Kruskal–Wallis test followed by Dunn tests. White triangles indicate IBA1⁺ COX2⁺ cells, red triangles indicate IBA1⁻ COX2⁺ cells, and green triangles indicate IBA1⁺ COX2⁻ cells. n = 5–6 mice per group.